Hygiene refers to conditions and practices that help to maintain health and prevent the spread of diseases. It is important to live in an environment that is free of incidence of hazardous waste, its impacts is usually felt in all aspects of life of the individual having contact with that environment. This research examines non-hygienic practices and it's implication on students' health in College of Health Sciences, Niger Delta University, Wilberforce Island, Amassoma,Bayelsa State, Nigeria. Three research specific objectives were used alongside three research questions which have been raised with the aim of achieving the objectives. The main purpose of this study is to find out the effect of non-hygienic practices and its implications on the students’ health based on refuse disposal in Niger Delta University, College of Health Science, Wilberforce Island, Bayelsa State, Nigeria. The specific objectives are: to ascertain the level of awareness of non-hygienic practices among students of College of Health Sciences; to determine the reasons for non-hygienic practices among students of College of Health Sciences; and to assess the effects of nonhygienic practices among students of College of Health Sciences. The related literatures were reviewed. The researcher made use of Health Beliefs Model for which this study was based on. The target population of this study was obtained from the total population of students in the College of Health Sciences which was 2,083. Considering the population, a sample size of 336 was generated using the Taro Yamani’s formula.